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2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.
Przybylski, D.; Rohwerder, T.; Dilßner, C.; Maskow, T.; Harms, H.; Müller, R. H. Exploiting mixtures of H2, CO2, and O2 for improved production of methacrylate precursor 2-hydroxyisobutyric acid by engineered Cupriavidus necator strains. Appl. Microbiol. Biotechnol. 2015, 99 (5), 2131-2145.
Lee, J.; Jung, Y.; Park, J. Y.; Lee, S. H.; Ryu, D. H.; Hwang, G. S. LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction. J. Pharm. Biomed. Anal. 2015, 115, 475-486.
Dichiarazioni di rischio (UE): H315-H318-H335
Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.