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421-53-4 - Trifluoroacetaldehyde hydrate, tech., ca 75% in water - 2,2,2-Trifluoro-1,1-ethanediol - A13234 - Alfa Aesar

A13234 Trifluoroacetaldehyde hydrate, tech., ca 75% in water

Codice CAS
421-53-4
Sinonimi
2,2,2-Trifluoro-1,1-ethanediol

Dimensioni Prezzo ($) Quantità Disponibilità
10g 82,71
50g 310,03
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Trifluoroacetaldehyde hydrate, tech., ca 75% in water

MDL
MFCD00167359
EINECS
207-006-4

Proprietà chimiche

Formula
C2H3F3O2
Peso formula
116.04(anhy)
Punto di ebollizione
104-106°
Punto di infiammabilità
None
Densità
1.44
Solubilità
Soluble in water.

Applicazioni

One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4 or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields. Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds.

Note

Store at room temperature. Incompatible with oxidizing agents. Keep in cool place.

Letteratura

G. K. Surya Prakash.; Zhe Zhang.; Fang Wang.; Socrates Munoz.; George A. Olah. Nucleophilic Trifluoromethylation of Carbonyl Compounds: Trifluoroacetaldehyde Hydrate as a Trifluoromethyl Source.J. Org. Chem. 2013, 78 (7),3300-3305 .

Mauno M. Airaksinen.; Per H. Rosenberg.; Tapani Tammisto. A Possible Mechanism of Toxicity of Trifluoroethanol and Other Halothane Metabolites.Acta Pharmacologica et Toxicologica. 1970, 28 (4),299-304 .

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H318-H315-H302-H317-H335

Highly flammable liquid and vapour. Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause an allergic skin reaction. May cause respiratory irritation.

Dichiarazioni precauzionali: P210-P261-P280-P303+P361+P353-P305+P351+P338-P304+P340-P310-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2905.59
TSCA
Yes
RTECS
KI2850000

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