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870-63-3 - 1-Bromo-3-methyl-2-butene, 90+%, stab. with silver - 3,3-Dimethylallyl bromide - Prenyl bromide - A13388 - Alfa Aesar

A13388 1-Bromo-3-methyl-2-butene, 90+%, stab. with silver

Codice CAS
870-63-3
Sinonimi
3,3-Dimethylallyl bromide
Prenyl bromide

Dimensioni Prezzo ($) Quantità Disponibilità
10g 32,96
50g 144,20
250g 678,77
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1-Bromo-3-methyl-2-butene, 90+%, stab. with silver

MDL
MFCD00000242
EINECS
212-799-5

Proprietà chimiche

Formula
C5H9Br
Peso formula
149.03
Punto di ebollizione
135°
Punto di infiammabilità
32°(90°F)
Densità
1.281
Indice di rifrazione
1.4895
Sensibilità
Light Sensitive
Solubilità
Immiscible with water

Applicazioni

1-Bromo-3-methyl-2-butene is considered as a source of 3,3-dimethylallyl group and used in the preparation of natural products. It is also employed in the synthesis of base-modified pyrimidine nucleosides. Further, it is used in the preparation of (±)-eldanolide, 1-(3,3-dimethylallyl)-L-tryptophan and (±)-fumagillin, an antibiotic isolated from Aspergillus fumigattus.

Note

Store in a cool place. Incompatible with strong oxidizing agents and strong bases

Letteratura

3,3-Dimethylallyl (prenyl) building block group, useful in terpene synthesis. For use as an alkylating agent, see, e.g.: Org. Synth. Coll., 8, 381 (1993).

In the presence of the hindered base lithium 2,2,6,6-tetramethylpiperidide (LTMP) forms a carbenoid species which reacts with alkenes to provide vinylcyclopropenes: Synlett, 647 (1991):

Fujii, S.; Shimizu, A.; Takeda, N.; Oguchi, K.; Katsurai, T.; Shirakawa, H.; Komai, M.; Kagechika, H. Systematic synthesis and anti-inflammatory activity of µ-carboxylated menaquinone derivatives-Investigations on identified and putative vitamin K2 metabolites. Bioorg. Med. Chem. 2015, 23 (10), 2344-2352.

Inagaki, R.; Ninomiya, M.; Tanaka, K.; Koketsu, M. Synthesis, Characterization, and Antileukemic Properties of Naphthoquinone Derivatives of Lawsone. ChemMedChem 2015, 10 (8), 1413-1423.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1420778
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2903.39
TSCA
Yes

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