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1660-95-3 - Tetraisopropyl methylenediphosphonate, 98% - Methylenediphosphonic acid tetraisopropyl ester - Methylenephosphonic acid tetraisopropyl ester - A13484 - Alfa Aesar

A13484 Tetraisopropyl methylenediphosphonate, 98%

Codice CAS
1660-95-3
Sinonimi
Methylenediphosphonic acid tetraisopropyl ester
Methylenephosphonic acid tetraisopropyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
10g 42,10
50g 148,00
250g 654,00
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Tetraisopropyl methylenediphosphonate, 98%

MDL
MFCD00015021
EINECS
216-765-0

Proprietà chimiche

Formula
C13H30O6P2
Peso formula
344.33
Punto di ebollizione
122-124°/1.5mm
Punto di infiammabilità
160°(320°F)
Densità
1.080
Indice di rifrazione
1.4340
Solubilità
Insoluble in water.

Applicazioni

Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. It is also used in the preparation of E2-bisphosphonate conjugates.

Note

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Letteratura

Richard D. Chambers.; John Hutchinson. Elemental fluorine. Part 91: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2. Journal of Fluorine Chemistry. 1998, 92, (1), 45-52.

Andrzej W. Trochimczuk. Novel ion-exchange/coordination resin with carboxyethyl phosphonate ligands. European Polymer Journal. 1998, 34, (7), 1047-1051.

Horner-Wadsworth-Emmons olefination (see Appendix 1) with carbonyl compounds yields vinylphosphonates: Synth. Commun., 10, 299 (1980). A synthesis of allenes via a double HWE olefination has been described: Tetrahedron, 58, 83 (2002):

gem-Bisphosphonates have application in bone tissue therapy: Synthesis, 661 (1991).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H318

Causes serious eye damage.

Dichiarazioni precauzionali: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1080180
Codice tariffe armonizzato
2931.39
TSCA
Yes

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