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Tetraisopropyl methylenediphosphonate is used in the preparation of AZT 5-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. It is also used in the preparation of E2-bisphosphonate conjugates.
Richard D. Chambers.; John Hutchinson. Elemental fluorine. Part 91: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2. Journal of Fluorine Chemistry. 1998, 92, (1), 45-52.
Andrzej W. Trochimczuk. Novel ion-exchange/coordination resin with carboxyethyl phosphonate ligands. European Polymer Journal. 1998, 34, (7), 1047-1051.
Horner-Wadsworth-Emmons olefination (see Appendix 1) with carbonyl compounds yields vinylphosphonates: Synth. Commun., 10, 299 (1980). A synthesis of allenes via a double HWE olefination has been described: Tetrahedron, 58, 83 (2002):
gem-Bisphosphonates have application in bone tissue therapy: Synthesis, 661 (1991).
Dichiarazioni di rischio (UE): H318
Causes serious eye damage.
Dichiarazioni precauzionali: P260-P201-P280i-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.