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13433-00-6 - Diethyl aminomalonate hydrochloride, 98% - Aminomalonic acid diethyl ester hydrochloride - A13681 - Alfa Aesar

A13681 Diethyl aminomalonate hydrochloride, 98%

Codice CAS
13433-00-6
Sinonimi
Aminomalonic acid diethyl ester hydrochloride

Dimensioni Prezzo ($) Quantità Disponibilità
10g 31,80
50g 106,00
250g 456,00
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Diethyl aminomalonate hydrochloride, 98%

MDL
MFCD00012510
EINECS
236-556-8

Proprietà chimiche

Formula
C7H13NO4•HCl
Peso formula
211.65
Punto di fusione
ca 165° dec.
Sensibilità
Hygroscopic
Solubilità
Soluble in water.

Applicazioni

Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. It is hygroscopic in nature. Incompatible with oxidizing agents.

Letteratura

Mario D. Bachi.; Nira Bar-Ner.; Charles M. Crittell.; Peter J. Stang.; Bobby L. Williamson. Synthesis of alkynyl(phenyl)iodonium triflates and their reaction with diethyl 2-aminomalonate. J. Org. Chem. 1991, 56 (12), 3912-3915.

Ning Chen.; Yuelie Lu.; Kumar Gadamasetti.; Clarence R. Hurt.; Mark H. Norman.; Christopher Fotsch. A Short, Facile Synthesis of 5-Substituted 3-Amino-1H-pyrrole-2-carboxylates. J. Org. Chem. 2000, 65 (8), 2603-2605.

Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines: Tetrahedron Lett., 29, 6649 (1988):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3568037
Codice tariffe armonizzato
2922.49
TSCA
No

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