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1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4'-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 '-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.
Lithiation with LDA occurs mainly ortho to F; subsequent carboxylation gives 5-chloro-2-fluorobenzoic acid in moderate yield: Tetrahedron Lett., 33, 7495 (1992). The selectivity is improved by the use of the superbasic combination of n-BuLi and KO-t-Bu, and the yield is increased to 86%: Tetrahedron Lett., 37, 6551 (1996).
Dichiarazioni di rischio (UE): H226-H332-H315-H319-H335
Flammable liquid and vapour. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.