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546-68-9 - Titanium(IV) isopropoxide, 95% - Tetraisopropoxytitanium(IV) - Tetraisopropyl orthotitanate - A13703 - Alfa Aesar

A13703 Titanium(IV) isopropoxide, 95%

Codice CAS
546-68-9
Sinonimi
Tetraisopropoxytitanium(IV)
Tetraisopropyl orthotitanate

Dimensioni Prezzo ($) Quantità Disponibilità
100g 22,90
500g 59,40
2500g 226,00
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Titanium(IV) isopropoxide, 95%

MDL
MFCD00008871
EINECS
208-909-6

Proprietà chimiche

Formula
C12H28O4Ti
Peso formula
284.23
Punto di fusione
16-20°
Punto di ebollizione
232°
Punto di infiammabilità
46°(115°F)
Densità
0.955
Indice di rifrazione
1.4640
Sensibilità
Moisture Sensitive
Solubilità
Soluble in anhydrous ethanol, ether, benzene and chloroform.

Applicazioni

Titanium(IV) isopropoxide is used as a precursor for the preparation of titanium and barium-strontium-titanate thin films. It is useful to make porous titanosilicates and potential ion-exchange materials for cleanup of radioactive wastes. It is an active component of sharpless epoxidation as well as involved in the synthesis of chiral epoxides. In Kulinkovich reaction, it is involved as a catalyst in the preparation of cyclopropanes.

Note

Moisture sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong acids. It reacts with water to produce titanium dioxide.

Letteratura

Catalyst for transesterification, avoiding acidic or basic conditions. The reaction is carried out such that one alcohol is removed to displace the equilibrium: Synthesis, 138 (1982); Org. Synth. Coll., 8, 201 (1993). For application to carbamates, including Boc to Cbz conversion, see: J. Org. Chem., 62, 7096 (1997).

For use in the Sharpless enantioselective epoxidation of allylic alcohols, see tert-Butyl­ hydroperoxide, A13926. For analogous enantioselective oxidation of sulfides to sulfoxides, see Cumene hydroperoxide, L06866. Epoxy alcohols can also be obtained in high yield in one pot by hydroperoxidation of alkenes with singlet oxygen in the presence of Ti(O-i-Pr)4: J. Am. Chem. Soc., 111, 203 (1989).

Also catalyzes the ring-opening of 2,3-epoxy alcohols (e.g. from the above reactions) with various nucleophiles, including amines, thiols, thiolate anions, halides, carboxylates etc. The mild conditions result in increased regioselectivity: J. Org. Chem., 50, 1557 (1985).

See also Dimethyl­amine hydrochloride, A12133.

For conversion of epoxides to episulfides, see Thiourea, A12828. For use in reductive alkylation of amines, see Sodium cyanoborohydride, 87839. For use in enantioselective synthesis of homoallylic alcohols, see (R)-(+)-1,1'-Bi(2-naphthol)­, L08305. For reduction of amides to aldehydes, see Diphenyl­silane, A10884.

For a brief feature on uses of the reagent, see: Synlett, 2261 (2003).

Khalil, K. M.; El-Khatib, R. M.; Ali, T. T.; Mahmoud, H. A.; Elsamahy, A. A. Titania nanoparticles by acidic peptization of xerogel formed by hydrolysis of titanium(IV) isopropoxide under atmospheric humidity conditions. Powder Technol. 2013, 245, 156-162.

Wanna, N.; Kraithong, T.; Khamnaen, T.; Phiriyawirut, P.; Charoenchaidet, S.; Tantirungrotechai, J. Aluminum-and calcium-incorporated MCM-41-type silica as supports for the immobilization of titanium(IV) isopropoxide in ring-opening polymerization of l-lactide and ε-caprolactone. Catal. Commun. 2014, 45, 118-123.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H226-H319

Flammable liquid and vapour. Causes serious eye irritation.

Dichiarazioni precauzionali: P210-P280-P240-P241-P233-P242-P303+P361+P353-P305+P351+P338-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9480
Beilstein
3679474
Classe di rischio
3
Gruppo di imballaggio
III
Codice tariffe armonizzato
2905.19
TSCA
Yes
RTECS
NT8060000

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