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10-Undecynoic acid may be employed as a biochemical probe in an assay for the microsomal hydroxylation of lauric acid (LA), based on HPLC with flow-through radiochemical detection. It was employed as model compound to investigate the microwave assisted surface click reactions catalyzed with Cu(II)/sodium L-ascorbate. It is reported as highly selective irreversible inhibitor of hepatic ω- and ω-1-lauric acid hydroxylases.
P R Ortiz de Montellano; N O Reich. Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids.Journal of Biological Chemistry.1984, 259 (7), 4136-4141.
Lenart J; Pikuła S 10-Undecynoic acid, an inhibitor of cytochrome P450 4A1, inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes.Acta Biochimica Polonica.1999, 46 (1), 203-210.
For use in the synthesis of long-chain ω-hydroxy acids, by acetylenic coupling with bromoacetylenic alcohols (from hypobromite bromination of alkynols), see: Synthesis, 230 (1984).
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.