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765-69-5 - 2-Methylcyclopentane-1,3-dione, 98% - A13936 - Alfa Aesar

A13936 2-Methylcyclopentane-1,3-dione, 98%

Codice CAS
765-69-5
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 28,20
25g 125,00
100g 470,00
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2-Methylcyclopentane-1,3-dione, 98%

MDL
MFCD00001406
EINECS
212-153-2

Proprietà chimiche

Formula
C6H8O2
Peso formula
112.13
Punto di fusione
212-216°
Solubilità
Solubility in hot Methanol (almost transparency).

Applicazioni

2-Methylcyclopentane-1,3-dione is an efficient synthon for the synthesis of (±)-α-cuparenone. The alkylation of 2-methylcyclopentane-1,3-dione (A) with 2-(1-naphthyl)ethyl bromide gives only the O-alkylation product. Mixtures of C- and O-alkyl derivatives are obtained. Michael addition of 2-methylcyclopentane-1,3-dione to methyl vinyl ketone in water gives 2-methyl-2-(3-oxo- butyl)-1,3-cyclopentanedione (3), an important intermediate of natural product chemistry. 2-Methylcyclopentane-1, 3-dione is an efficient synthon for the synthesis of (±)-α-cuparenone.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Letteratura

Joseph P. John,; S. Swaminathan,; P. S. Venkataramani. 2-Methylcyclopentane-1,3-Dione. Organic Syntheses. year of publication , volume issue , pg no.

Victor J. Grenda,; Glenn W. Lindberg,; Norman L. Wendler,; Seemon H. Pines. A convenient synthesis of 2-methylcyclopentane-1,3-dione . J. Org. Chem. 1967, 32 (4), 1236-1237.

Valuable intermediate for steroid synthesis. For a review, see: Synthesis, 477 (1989). Condensation with methyl vinyl ketone and proline-catalyzed asymmetric aldol cyclization of the product gives a diketone useful in steroid and prostaglandin synthesis: Org. Synth. Coll., 7, 363 (1990):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1237255
Codice tariffe armonizzato
2914.29
TSCA
No

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