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7803-57-8 - Hydrazine monohydrate, 98+% - A14005 - Alfa Aesar

A14005 Hydrazine monohydrate, 98+%

Codice CAS
7803-57-8
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
50g 16,70
250g 39,60
500g 56,40
2500g 226,00
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Hydrazine monohydrate, 98+%

MDL
MFCD00149931
EINECS
206-114-9

Proprietà chimiche

Formula
H4N2•H2O
Peso formula
50.06 (32.05anhy)
Punto di fusione
-52°
Punto di ebollizione
120-121°
Punto di infiammabilità
75°(167°F)
Densità
1.027
Indice di rifrazione
1.4310
Solubilità
Miscible with water and alcohol. Immiscible with chloroform, hydrocarbons and ether.

Applicazioni

Hydrazine monohydrate is used as a reducing agent. It is also used in water treatment, especially effluents and industrial boilers, metal treatment and mine extraction process, and synthesis of active ingredients in the pharmaceutical industry like 3-amino-1,2,4-triazole cefazolin, rizatriptan, anastrozole, fluconazole, metazachlor metamitron pyrazole, metribuzin, paclobutrazol, diclobutrazole, propiconazole, and triadimefon. It is involved in the preparation of heterocycles like pyrazoles and pyridazines. It is actively involved in the Wolff-Kishner reduction, which converts the carbonyl group of a ketone into a methylene bridge through a hydrazone intermediate. Further, it is used to cleave N-alkylated phthalimide derivatives. In the Einhorn-Brunner reaction, it reacts with imides to get triazoles.

Note

Special handling precautions required. View MSDS prior to purchase. MSDS are available online at www.alfa.comIncompatible with oxidizing agents, oxygen, copper, organic materials and zinc.

Letteratura

Forms stable, water-free solid complexes consisting of one hydrazine molecule associated with one molecule of hydroquinone or two molecules of 4-methoxyphenol. These have potential as replacements for the very hazardous anhydrous hydrazine, e.g. in the solid state reaction with esters to give pure hydrazides: J. Chem. Soc., Chem. Commun., 1531, (1995).

Diimide precursor: for generation of diimide by oxidation with O2, and use in selective reduction of a double bond in the presence of a cyclopropane ring, see: J. Chem. Soc., Chem. Commun., 525 (1973). Review of diimide reductions: Org. React., 40, 91 (1991). See also Hydroxyl­amine-O-sulfonic acid, A12560 .

In the Wolff-Kishner carbonyl to methylene reduction (heating with hydrazine and alkali hydroxide), diethylene glycol is now the usual solvent (the Huang Minlon modification): J. Am. Chem. Soc., 68, 2487 (1946); Org. Synth. Coll., 4, 510 (1963). The reduction has also been performed at ambient temperature by the use of KO-t-Bu in DMSO: J. Am. Chem. Soc., 84, 1734 (1962). See also Isatin, A12468 for an analogous reduction.

In the presence of Rh on carbon, nitrobenzene is selectively reduced to phenylhydroxylamine: Org. Synth. Coll., 8, 16 (1993).

For a brief feature on uses of the reagent in synthesis, see: Synlett, 2445 (2004).

Shiraishi, Y.; Hirakawa, H.; Hirai, T. Photocatalytic Hydrogenation of Nitroaromatics to Anilines on Silica-Supported Iron Oxides with Hydrazine Monohydrate as a Reductant. J. Chem. Eng. Jpn. 2015, 48 (2), 141-146.

Sun, J. K.; Xu, Q. Metal Nanoparticles Immobilized on Carbon Nanodots as Highly Active Catalysts for Hydrogen Generation from Hydrazine in Aqueous Solution. Chem. Cat. Chem. 2015, 7 (3), 526-531.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H301-H310-H330-H314-H318-H317-H350

Combustible liquid. Toxic if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction. May cause cancer.

Dichiarazioni precauzionali: P301+P310a-P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,4771
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2825.10
TSCA
Yes
RTECS
MV4590000

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