1-Bromo-3-chlorobenzene undergoes bromine-magnesium exchange reactions with i-PrMgCl-LiCl in THF at 0°C and is strongly accelerated by electron-withdrawing substituents. It acts as test substrate to study the application of a new catalytic system for cyanation of various aryl halides using K4[Fe(CN)6] as cyanating source.
Lei Shi; Yuanyuan Chu; Paul Knochel; Herbert Mayr. Kinetics of bromine-magnesium exchange reactions in substituted bromobenzenes. Journal of Organic Chemistry. 2009, 74,(7), 2760-2764.
M.Mahmoodi-Darian; S.X.Tian; S.Denifl; S.Matejcik; T.D.Mark; P.Scheier. Temperature dependence of dissociative electron attachment to 1-bromo-2-chlorobenzene and 1-bromo-3-chlorobenzene. International Journal of Mass Spectrometry. 2010, 293,(1-3), 51-55.
Dichiarazioni di rischio (UE): H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.