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1H-Pyrazole is used as a ligand in the preparation of organometallic compounds. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.
Michael S. Bernatowicz; Youling Wu; Gary R. Matsueda. 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis. J. Org. Chem. 1992, 57 (8), 2497-2502.
Adnan A. Bekhit; Hayam M.A. Ashour; Yasser S. Abdel Ghany; Alaa El-Din A. Bekhit; Azza Baraka. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. European Journal of Medicinal Chemistry. 2008, 43 (3), 456-463.
Forms a complex with Pyridinium chlorochromate, A11752, which allows the selective oxidation of allylic alcohols in the presence of non-allylic alcohols: Lipids, 19, 550 (1984).
Can be protected on nitrogen by hydroxymethylation with paraformaldehyde, permitting 3-lithiation with t-BuLi: Tetrahedron, 45, 4253 (1989).
Dichiarazioni di rischio (UE): H302-H315-H319-H361-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Suspected of damaging fertility or the unborn child. May cause respiratory irritation.
Dichiarazioni precauzionali: P201-P261-P280-P305+P351+P338-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.