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76-05-1 - Trifluoroacetic acid, biochemical grade, 99.5+% - A14365 - Alfa Aesar

A14365 Trifluoroacetic acid, biochemical grade, 99.5+%

Codice CAS
76-05-1
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
50g 40,09
250g 113,30
1000g 353,29
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Trifluoroacetic acid, biochemical grade, 99.5+%

MDL
MFCD00004169
EINECS
200-929-3

Proprietà chimiche

Formula
CF3CO2H
Peso formula
114.02
Punto di fusione
-15°
Punto di ebollizione
72-73°
Densità
1.480
Indice di rifrazione
1.2840
Sensibilità
Hygroscopic
Solubilità
Miscible with ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Applicazioni

Used to cleave peptide blocking groupsThe combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Note

Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Letteratura

López, S. E.; Salazar, J. Trifluoroacetic acid: Uses and recent applications in organic synthesis. J. Fluorine Chem. 2013, 156, 73-100.

Natu, A. D.; Burde, A. S.; Limaye, R. A.; Paradkar, M. V. Acceleration of the Dakin reaction by trifluoroacetic acid. J. Chem. Res. 2014, 38 (6), 325-386.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H332-H412

Causes severe skin burns and eye damage. Harmful if inhaled. Harmful to aquatic life with long lasting effects.

Dichiarazioni precauzionali: P260-P261-P273-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9681
Beilstein
742035
Classe di rischio
8
Gruppo di imballaggio
I
Codice tariffe armonizzato
2915.90
TSCA
Yes
RTECS
AJ9625000

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