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499-80-9 - Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water - Lutidinic acid - A14409 - Alfa Aesar

A14409 Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

Codice CAS
499-80-9
Sinonimi
Lutidinic acid

Dimensioni Prezzo ($) Quantità Disponibilità
5g 56,80
25g 241,00
100g 771,00
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Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

MDL
MFCD00149413
EINECS
207-892-2

Proprietà chimiche

Formula
C7H5NO4
Peso formula
167.12
Punto di fusione
ca 245° dec.
Solubilità
Soluble in water at 20°C 4.5 g/L.

Applicazioni

It is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. It blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,3 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), It modulates hypoxia inducing factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.8 2,4-PDCA also affects and is translocated by organic anion transporters.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Line H Kristensen, et al. Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.FEBS J.,2012,279(11), 1905-1914.

Koski, M.K, et al.The active site of an algal prolyl 4-hydroxylase has a large structural plasticity. Biol Chem.,2007,282(51), 37112-37123.

Mackeen, et al. Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. J Proteome Res.,2010,9(8), 4082-4092.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
131631
Codice tariffe armonizzato
2933.39
TSCA
Yes

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