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354-38-1 - 2,2,2-Trifluoroacetamide, 97% - A14451 - Alfa Aesar

A14451 2,2,2-Trifluoroacetamide, 97%

Codice CAS
354-38-1
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
25g 37,20
100g 102,00
500g 310,00
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2,2,2-Trifluoroacetamide, 97%

MDL
MFCD00008008
EINECS
206-559-9

Proprietà chimiche

Formula
CF3CONH2
Peso formula
113.04
Punto di fusione
70-75°
Punto di ebollizione
162-164°
Solubilità
Soluble in water (460 g/L at 20°C), alcohol, ether, chloroform (partially), and methanol.

Applicazioni

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Letteratura

Chuan-Zhou Tao.; Juan Li.; Yao Fu.; Lei Liu.; Qing-Xiang Guo. Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide. Tetrahedron Letters. 2008, 49 (1), 70-75.

Snefrid Gundersen.; Svein Samdal.; Ragnhild Seip.; Dmitry J. Shorokhov.; Tor G. Strand. Applequist. The molecular structure, conformation, potential to internal rotation and force field of 2,2,2-trifluoroacetamide as studied by gas electron diffraction and quantum chemical calculations. Journal of Molecular Structure. 1998, 445 (1-3), 229-242.

Has been used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group: Synthesis, 941 (1984). For improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups, see: Synth. Commun., 18, 791 (1988). The method has been further extended by the use of ɑ-bromo esters to provide a high yielding route to ɑ-amino acids: J. Org. Chem., 56, 420 (1991):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1753625
Codice tariffe armonizzato
2924.19
TSCA
Yes

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