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59-88-1 - Phenylhydrazine hydrochloride, 99% - A14645 - Alfa Aesar

A14645 Phenylhydrazine hydrochloride, 99%

Codice CAS
59-88-1
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100g 61,40
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Phenylhydrazine hydrochloride, 99%

MDL
MFCD00012924
EINECS
200-444-7

Proprietà chimiche

Formula
C6H8N2•HCl
Peso formula
144.61
Punto di fusione
ca 252° dec.
Solubilità
Soluble in water and alcohol.

Applicazioni

Phenylhydrazine hydrochloride is used as a selective mannosidase inhibitor. It is used in the study of tyrosine phosphorylation of janus protein tyrosine kinase in the EPO-responsive normal erythroblastoid cells of anemic mice. It is used in steroid assays and as an N-protecting reagent. Its free base, phenylhydrazine is used to prepare indoles, which find application as intermediates in the synthesis of various dyes and pharmaceuticals.

Note

Air and light sensitive. Hygroscopic. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and bases.

Letteratura

Butin, A. V.; Uchuskin, M. G.; Pilipenko, A. S.; Serdyuk, O. V.; Trushkov, I. V. Unusual reactivity of beta-(3-indolyl)-alpha, beta-unsaturated ketones. 2-Acetylvinyl group removal by phenylhydrazine hydrochloride. Tetrahedron Lett. 2011, 52 (41), 5255-5258.

Muralirajan, K.; Haridharan, R.; Prakash, S.; Cheng, C. H. Rhodium(III)-Catalyzed in situ Oxidizing Directing Group-Assisted C? H Bond Activation and Olefination: A Route to 2-Vinylanilines. Adv. Synth. Catal. 2015, 357, (4), 761-766.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H311-H331-H315-H319-H317-H350-H372-H341-H400

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause cancer. Causes damage to organs through prolonged or repeated exposure. Suspected of causing genetic defects. Very toxic to aquatic life.

Dichiarazioni precauzionali: P260-P201-P261-P273-P280-P301+P310-P305+P351+P338-P361-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,7293
Beilstein
3594958
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2928.00
TSCA
Yes
RTECS
MV9000000

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