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683-08-9 - Diethyl methylphosphonate, 97% - Diethyl methanephosphonate - Methylphosphonic acid diethyl ester - A14772 - Alfa Aesar

A14772 Diethyl methylphosphonate, 97%

Codice CAS
683-08-9
Sinonimi
Diethyl methanephosphonate
Methylphosphonic acid diethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
10g 90,20
25g 187,00
50g 362,00
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Diethyl methylphosphonate, 97%

MDL
MFCD00009813
EINECS
211-667-4

Proprietà chimiche

Formula
C5H13O3P
Peso formula
152.13
Punto di ebollizione
194°
Punto di infiammabilità
75°(167°F)
Densità
1.040
Indice di rifrazione
1.4140
Solubilità
Miscible with water.

Applicazioni

Diethyl methylphosphonate is used as a precursor for the synthesis of gem-difluroalkenyphosphonate via reaction with alpha-trifluromethylstyrene. It is also used in the synthesis of phosphonylated peptides, fluoroalkyl alpha- and beta-aminophosphonates, pyridone alkaloids with neuritogenic activity and lipophilic meropenem-derived prodrugs.

Note

Incompatible with strong oxidizing agents and strong bases.

Letteratura

For synthetic applications of the lithio-derivatives of esters of methanephosphonic acid, see Dimethyl­ methyl­phosphonate, A14268.

Dialkylation has been used in the synthesis of cyclobutanephosphonates which are intermediates in the synthesis of 3-phosphonocyclobutyl amino acids: J. Chem. Soc., Perkin 1, 493 (1997).

Reaction of the lithio-derivative with dialkyl cyanamides gives, instead of the expected 2-phosphorylacetamide, a rearranged N-phosphorylated amidine: Chem. Commun., 609 (1998):

Mattea, F.; Peters, C. J.; Kroon, M. C. Experimental Determination of the Solubilities of CO2 and CH4 in Diethyl Methylphosphonate. J. Chem. Eng. Data 2011, 56 (6), 2960-2963.

JeongaJang, Y.; Murale, D. P.; Churchill, D. G. Novel reversible and selective nerve agent simulant detection in conjunction with superoxide “turn-on” probing. Analyst 2014, 139 (7), 1614-1617.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P260-P201-P280a-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1753416
Codice tariffe armonizzato
2931.39
TSCA
No
RTECS
SZ9085000

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