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5329-33-9 - O-Methylisourea hydrochloride, 98% - A14773 - Alfa Aesar

A14773 O-Methylisourea hydrochloride, 98%

Codice CAS
5329-33-9
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
10g 68,60
50g 301,79
250g 990,40
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O-Methylisourea hydrochloride, 98%

MDL
MFCD00035043

Proprietà chimiche

Formula
C2H6N2O•HCl
Peso formula
110.54
Punto di fusione
ca 116° dec.
Solubilità
Soluble in organic solvents, water, methanol and ethanol.

Applicazioni

O-methylisourea hydrochloride is used to prepare 1-chloro-2-methyl-isourea. It is also used as an organic intermediate.

Note

Incompatible with strong oxidizing agents.

Letteratura

Useful intermediate, more nucleophilic than urea itself, and avoiding toxicity of thiourea, in the synthesis of pyrimidines, by condensation with ß-diketones: Chem. Ber., 109, 3255 (1976); and of uracils, by condensation with ß-keto esters: Tetrahedron, 40, 3313 (1984); J. Heterocycl. Chem., 26, 883 (1989).

Reagent for guanylation of primary and secondary amines: Chem.-Ztg., 98, 617 (1974).

Reagent for selective methylation of SH groups at pH 8.5: Biochemistry, 9, 3343 (1970); 11, 110 (1972).

For a review of the synthetic applications of isoureas, see: Org. Prep. Proced. Int., 12, 309 (1980).

Paul, S.; Pattanayak, S.; Sinha, S. Synthesis and cell transfection properties of cationic uracil-morpholino tetramer. Tetrahedron Lett. 2014, 55 (5), 1072-1076.

Le?tinois, U.; Schu?tz, J.; Ha?rter, R.; Stoll, R.; Huffschmidt, F.; Bonrath, W.; Karge, R. Lewis acid-catalyzed synthesis of 4-aminopyrimidines: a scalable industrial process. Org. Process Res. Dev. 2013, 17 (3), 427-431.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3909619
Codice tariffe armonizzato
2924.19
TSCA
Yes

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