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A14773 O-Methylisourea hydrochloride, 98%

Codice CAS

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
A14773-09 10g 68,60
A14773-18 50g 302,00
A14773-30 250g 1276,00
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O-Methylisourea hydrochloride, 98%


Proprietà chimiche

Peso formula
Punto di fusione
ca 116° dec.
Storage & Sensitivity
Ambient temperatures.
Soluble in organic solvents, water, methanol and ethanol.


O-methylisourea hydrochloride is used to prepare 1-chloro-2-methyl-isourea. It is also used as an organic intermediate.


Incompatible with strong oxidizing agents.


Useful intermediate, more nucleophilic than urea itself, and avoiding toxicity of thiourea, in the synthesis of pyrimidines, by condensation with ß-diketones: Chem. Ber., 109, 3255 (1976); and of uracils, by condensation with ß-keto esters: Tetrahedron, 40, 3313 (1984); J. Heterocycl. Chem., 26, 883 (1989).

Reagent for guanylation of primary and secondary amines: Chem.-Ztg., 98, 617 (1974).

Reagent for selective methylation of SH groups at pH 8.5: Biochemistry, 9, 3343 (1970); 11, 110 (1972).

For a review of the synthetic applications of isoureas, see: Org. Prep. Proced. Int., 12, 309 (1980).

Paul, S.; Pattanayak, S.; Sinha, S. Synthesis and cell transfection properties of cationic uracil-morpholino tetramer. Tetrahedron Lett. 2014, 55 (5), 1072-1076.

Le?tinois, U.; Schu?tz, J.; Ha?rter, R.; Stoll, R.; Huffschmidt, F.; Bonrath, W.; Karge, R. Lewis acid-catalyzed synthesis of 4-aminopyrimidines: a scalable industrial process. Org. Process Res. Dev. 2013, 17 (3), 427-431.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato


  • B21675

    Trichloroacetyl chloride, 99%
  • H27499

    (S)-1-Cyclopropylethylamine, ChiPros®, 98%, ee 98+%

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