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Pyrrolidine is used as building block in the synthesis of organic compounds. It is used to activate ketones and aldehydes toward nucleophilic addition. It is also utilized in promoting aldol condensation of ketones and aldehydes by forming enamine.
Pohl, R.; Slavětínská, L. P.; Eng, W. S.; Keough, D. T.; Guddat, L. W.; Rejman, D. Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Org. Biomol. Chem. 2015, 13, 4693-4705.
Redondo, J. A.; Velasco, D.; Pérez-Perrino, M.; Reinecke, H.; Gallardo, A.; Pandit, A.; Elvira, C. Synergistic effect of pendant hydroxypropyl and pyrrolidine moieties randomly distributed along polymethacrylamide backbones on in vitro DNA-transfection. Eur. J. Pharm. Biopharm. 2015, 90, 38-43.
Dichiarazioni di rischio (UE): H225-H301-H332-H314-H318
Highly flammable liquid and vapour. Toxic if swallowed. Harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P210-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.