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4637-24-5 - N,N-Dimethylformamide dimethyl acetal, 97% - 1,1-Dimethoxy-N,N-dimethylmethylamine - A15350 - Alfa Aesar

A15350 N,N-Dimethylformamide dimethyl acetal, 97%

Codice CAS
4637-24-5
Sinonimi
1,1-Dimethoxy-N,N-dimethylmethylamine

Dimensioni Prezzo ($) Quantità Disponibilità
25g 36,80
100g 104,00
500g 382,00
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N,N-Dimethylformamide dimethyl acetal, 97%

MDL
MFCD00008482
EINECS
225-063-3

Proprietà chimiche

Formula
(CH3)2NCH(OCH3)2
Peso formula
119.16
Punto di fusione
-85°
Punto di ebollizione
102-104°
Punto di infiammabilità
7°(45°F)
Densità
0.897
Indice di rifrazione
1.3972
Sensibilità
Moisture Sensitive
Solubilità
Miscible with most organic solvents.

Applicazioni

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Note

Moisture sensitive. Incompatible with strong oxidizing agents and acids.

Letteratura

Lee, H. J.; Lee, S.; Yu, J.; Kim, J. N. Vinylogous N,N-dimethylaminomethylenation of 3-[(1-substituted) ethylidene]-oxindoles with N,N-dimethylformamide dimethylacetal. Tetrahedron Lett. 2014, 55 (15), 2450-2454.

Prek, B.; Grošelj, U.; Kasunič, M.; Zupančič, S.; Svete, J.; Stanovnik, B. Reactions of Methyl Ketones and (Hetero)arylcarboxamides with N, N-Dimethylacetamide Dimethyl Acetal. A Simple Metal-Free Synthesis of 2, 4, 6-Trisubstituted Pyridines. Aust. J. Chem. 2015, 68 (2), 184-195.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H302-H332-H315-H319-H335

Highly flammable liquid and vapour. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2911.00
TSCA
Yes

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