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1622-32-8 - 2-Chloroethanesulfonyl chloride, 98% - 2-Chloroethylsulfonyl chloride - A15377 - Alfa Aesar

A15377 2-Chloroethanesulfonyl chloride, 98%

Codice CAS
1622-32-8
Sinonimi
2-Chloroethylsulfonyl chloride

Dimensioni Prezzo ($) Quantità Disponibilità
10g 42,10
50g 179,00
100g 302,00
250g 755,00
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2-Chloroethanesulfonyl chloride, 98%

MDL
MFCD00007461
EINECS
216-594-1

Proprietà chimiche

Formula
C2H4Cl2O2S
Peso formula
163.02
Punto di ebollizione
203°
Punto di infiammabilità
>110°(230°F)
Densità
1.560
Indice di rifrazione
1.4915
Sensibilità
Moisture Sensitive
Solubilità
Reacts with water.

Applicazioni

2-Chloroethanesulfonyl chloride was used in one-pot sulfonylation/intramolecular thia-Michael protocol for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. It was also used in synthesis of vinyl sulfonamides with a furan, carbocyclic, semi cyclic or acyclic 1,3-diene moiety.

Note

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents. Store in refrigerator.

Letteratura

James Frederick King; Kishan Chand Khemani. The mechanism of hydrolysis of 2-hydroxyethanesulfonyl chloride: the intermediacy of 1,2-oxathietane 2,2-dioxide (β-sultone). Canadian Journal of Chemistry. 1989, 67 (12), 2162-2172.

C. W. Huffman. Formylation of Amines. J. Org. Chem. 1958, 23 (5), 727-729.

In the presence of a base, converts alcohols to vinyl sulfonates: J. Am. Chem. Soc., 68, 1797 (1946); Angew. Chem. Int. Ed., 4, 300 (1965). These electrophilic alkenes readily undergo conjugate addition reactions with various nucleophiles:

Reaction with pentafluorophenol, in the presence of Et3N, gives PFP vinylsulfonate, which can be converted to a sulfonamide via tin-mediated radical addition of alkyl halides to the olefinic bond, followed by displacement of the PFP group with an amine: Org. Lett., 42549 (2002).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H330-H314-H318

Toxic if swallowed. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P284-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1751202
Classe di rischio
6.1
Gruppo di imballaggio
I
Codice tariffe armonizzato
2904.90
TSCA
Yes
RTECS
KI8060000

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