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1899-93-0 - m-Toluenesulfonyl chloride, 98% - 3-Methylbenzenesulfonyl chloride - A15458 - Alfa Aesar

A15458 m-Toluenesulfonyl chloride, 98%

Codice CAS
1899-93-0
Sinonimi
3-Methylbenzenesulfonyl chloride

Dimensioni Prezzo ($) Quantità Disponibilità
1g 20,48
5g 49,25
25g 195,00
100g 561,60
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m-Toluenesulfonyl chloride, 98%

MDL
MFCD00051747

Proprietà chimiche

Formula
C7H7ClO2S
Peso formula
190.65
Punto di ebollizione
252-253°
Punto di infiammabilità
107°(224°F)
Densità
1.314
Indice di rifrazione
1.5480
Sensibilità
Moisture Sensitive
Solubilità
Reacts with water.

Applicazioni

Reactant involved in they synthesis of biologically active molecules including small molecule ligands for the Stat3 SH2 domain, aryldisulfonamides with antibacterial activity, quinazoline analogs for the treatment of Gaucher disease, 17β-HSD2 inhibitors for the treatment of osteoporosis, isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors.

Note

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents.

Letteratura

Wen-Hsing Lin; Shu-Yi Hsieh; Shih-Chieh Yen; Chiung-Tong Chen; Teng-Kuang Yeh; Tsu Hsu; Cheng-Tai Lu; Ching-Ping Chen; Chun-Wha Chen; Ling-Hui Chou; Yu-Lin Huang; An-Huei Cheng; Yun-I Chang; Ya-Ju Tseng; Kuei-Rong Yen; Yu-Sheng Chao; John T.-A. Hsu; Weir-Torn Jiaang. Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & Medicinal Chemistry. 2011, 19 (14), 4173-4182.

Brent D G Page; Steven Fletcher; Peibin Yue; Zhihua Li; Xiaolei Zhang; Sumaiya Sharmeen; Alessandro Datti; Jeffrey L Wrana; Suzanne Trudel; Aaron D Schimmer; James Turkson; Patrick T Gunning. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (18), 5605-5609.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2087865
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2904.90
TSCA
No

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