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7681-82-5 - Sodium iodide, 99+% (dry wt., water <1.0%) - A15480 - Alfa Aesar

A15480 Sodium iodide, 99+% (dry wt., water <1.0%)

Codice CAS
7681-82-5
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
100g 35,43
500g 134,93
2500g 527,36
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Sodium iodide, 99+% (dry wt., water <1.0%)

MDL
MFCD00003532
EINECS
231-679-3

Proprietà chimiche

Formula
NaI
Peso formula
149.89
Punto di fusione
651°
Punto di ebollizione
1300-1304°
Densità
3.67
Indice di rifrazione
1.7745
Sensibilità
Hygroscopic
Solubilità
Very soluble in water and liquid ammonia. Freely soluble in acetone, formic acid, formamide, methanol, and acetonitrile. Soluble in N,N-dimethylformamide.

Applicazioni

Sodium iodide is widely used for halide exchange (Finkelstein reaction), for example in the conversion of an alkyl chloride, allyl chloride and arylmethyl chloride into their respective iodides, which are precursors for pharmaceutical and fine chemical products. They are used to ehnance the efficiency of the formation of Wittig adducts from less reactive chlorides and bromides. Appropriate prepartions find use as a nutrient supplement. Sodium iodide is used as the precursor to the control agent in ab initio emulsion polymerization. Sodium iodide finds use in the determination of dissolved oxygen in the modified Winkler method, synthesis of the fluorescent dye coppersensor-1 (CS1) for imaging labile copper pools in biological samples, and the cleavage of esters, lactones, carbamates and ethers in combination with chlorotrimethylsilane.

Note

Deliquescent. Store in a tightly closed container. Incompatible with strong oxidizing agents and acids.

Letteratura

Converts alkyl chlorides or bromides to iodides (Finkelstein reaction). Preferred solvents are acetone or MEK, in which NaI, but not the chloride or bromide, is soluble. See, e.g.: Org. Synth. Coll., 2, 476 (1955); 4, 84 (1963). Activated aryl halides, such as 1-chloro-2,4-dinitrobenzene can be converted to iodides by reaction with NaI in DMF: Org. Synth. Coll., 5, 478 (1973).

Frequently used in catalytic amounts to increase the rate of nucleophilic displacement reactions of alkyl halides and sulfonates; see, for example: Org. Synth. Coll., 9, 46 (1998).

Ethers can be cleaved to ω-iodo esters with a combination of NaI and an acyl chloride: Tetrahedron Lett., 23, 681 (1982). Cleavage of ethers also occurs in the presence of TMS chloride: Angew. Chem. Int. Ed., 20, 690 (1981); J. Org. Chem., 44, 1247 (1979); 48, 3667 (1983). The same combination also reduces benzylic alcohols to arylmethanes: Tetrahedron Lett., 28, 3817 (1987); Bull. Chem. Soc. Jpn., 62, 3537 (1989) and deprotects MEM ethers: Tetrahedron Lett., 25, 1429 (1984); see 2-Methoxyethoxymethyl­ chloride, L01050.

In combination with Titanium(IV)­ chloride, 14713, reduction of amine oxides and nitrones occurs: Chem. Ber., 123, 647 (1990). Similarly, sulfoxides are reduced to sulfides: Synthesis, 155 (1991), and mild reductive deoximation can be effected: Synth. Commun., 21,1777 (1991).

Penheiter, A. R.; Russell, S. J.; Carlson, S. K. The Sodium Iodide Symporter (NIS) as an Imaging Reporter for Gene, Viral, and Cell-based Therapies. Curr. Gene Ther. 2012, 12, (1), 33-47.

Tonnar, J.; Lacroix-Desmazes, P. Use of Sodium Iodide as the Precursor to the Control Agent in Ab Initio Emulsion Polymerization. Angew. Chem. Int. Ed. 2008, 47, 1294-1297.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335-H303

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,8631
Codice tariffe armonizzato
2827.60
TSCA
Yes
RTECS
WB6475000

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