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638-07-3 - Ethyl 4-chloroacetoacetate, 97% - 4-Chloroacetoacetic acid ethyl ester - A15641 - Alfa Aesar

A15641 Ethyl 4-chloroacetoacetate, 97%

Codice CAS
638-07-3
Sinonimi
4-Chloroacetoacetic acid ethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
50g 26,01
250g 73,80
1000g 235,20
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Ethyl 4-chloroacetoacetate, 97%

MDL
MFCD00000939
EINECS
211-317-0

Proprietà chimiche

Formula
C6H9ClO3
Peso formula
164.59
Punto di fusione
-8°
Punto di ebollizione
220°
Punto di infiammabilità
92°(198°F)
Densità
1.212
Indice di rifrazione
1.4520
Solubilità
Miscible with water and most organic solvents.

Applicazioni

Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

Note

Incompatible with strong acids, strong bases, reducing agents and strong oxidizing agents. Store in a cool place.

Letteratura

Reacts at the 2-position with isocyanates in the presence of base to give 2-aminofuranone derivatives via a ketene N-acetal intermediate: Chem. Ber., 109, 212 (1976):

Isothiocyanates similarly give 2-aminothiophenones: J. Chem. Soc., Perkin 1, 1078 (1981).

Acid-catalyzed reaction with phenols gives 3-(chloromethyl)coumarins, readily convertible to benzofuran-3-acetic acids: Heterocycles, 41, 647 (1995):

Roslan, I. I.; Lim, Q. X.; Han, A.; Chuah, G. K.; Jaenicke, S. Solvent-Free Synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-ones Catalyzed by BiCl3: A Green Route to a Privileged Backbone. Eur. J. Org. Chem. 2015, 2015 (11), 2351-2355.

Wang, Y. J.; Liu, X. Q.; Luo, X.; Liu, Z. Q.; Zheng, Y. G. Cloning, expression and enzymatic characterization of an aldo-keto reductase from Candida albicans XP1463. J. Mol. Catal. B: Enzym. 2015, 122, 44-50.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H314-H318-H227-H401-H411

Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid. Toxic to aquatic life. Toxic to aquatic life with long lasting effects.

Dichiarazioni precauzionali: P210-P260-P273-P280-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1761275
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2918.30
TSCA
Yes
RTECS
AK5110000

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