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675-14-9 - Cyanuric fluoride, 98% - 2,4,6-Trifluoro-1,3,5-triazine - A15666 - Alfa Aesar

A15666 Cyanuric fluoride, 98%

Codice CAS

Dimensioni Prezzo ($) Quantità Disponibilità
5g 89,70
10g 157,00
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Cyanuric fluoride, 98%


Proprietà chimiche

Peso formula
Punto di fusione
Punto di ebollizione
Indice di rifrazione
Moisture Sensitive
Miscible with chloroform, carbon tetrachloride,ether, dioxane and ketones.


Cyanuric fluoride acts as a fluorinating agent used in the conversion of carboxylic acids into acyl fluorides. It is used as a precursor for fibre-reactive dyes. It is a specific reagent for tyrosine residues in enzyme. Further, it is involved in the preparation of cyanuric acid by hydrolysis


May precipitate upon storage. Moisture sensitive. Incompatible strong oxidizing agents, strong bases and alcohols.


In combination with pyridine, converts carboxylic acids to acyl fluorides in high yields under mild conditions: Synthesis, 487 (1973). Similarly, protected (Fmoc) amino acids are converted in dichloromethane solution to amino acid fluorides. tert-Butyl ester and ether groups are also stable under these conditions. The resulting acyl fluorides are more stable to water than the corresponding acyl chlorides but are more reactive to amines, thus providing a useful peptide coupling method: J. Am. Chem. Soc., 112, 9651 (1990); Tetrahedron, 50, 5309 (1994); Appendix 6. For use of Fmoc amino acid fluorides in solid-phase peptide synthesis, see: Tetrahedron Lett., 32, 1303 (1991); J. Org. Chem., 59, 3275 (1994). For a review of peptide synthesis via amino acid halides, see: Acc. Chem. Res., 29, 268 (1996).

Carboxylic acids can be converted to alcohols under mild conditions via the acyl fluoride and reduction with NaBH4 in the presence of MeOH. The method can be carried out in one pot and is applicable to N-protected amino acids and peptides for which other reduction methods are unsuitable: J. Org. Chem., 61, 6994 (1996).

Reagent for deoxygenation of alkyl sulfoxides, cf Cyanuric chloride, L03442 : Synthesis, 221 (1980), and for dehydration, at room temperature in DMF, of Boc amino acid amides to nitriles: Tetrahedron. Lett., 38, 4221 (1997).

Prabhaharan, M.; Prabakaran, A. R.; Gunasekaran, S.; Srinivasan, S. DFT studies on vibrational spectra, HOMO-LUMO, NBO and thermodynamic function analysis of cyanuric fluoride. Spectrochim. Acta, Part A 2015, 136, 494-503.

Guo, W.; Pleixats, R.; Shafir, A.; Parella, T. Rhodium Nanoflowers Stabilized by a Nitrogen-Rich PEG-Tagged Substrate as Recyclable Catalyst for the Stereoselective Hydrosilylation of Internal Alkynes. Adv. Synth. Catal. 2015, 357 (1), 89-99.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H310-H330-H314-H318

Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P284-P303+P361+P353-P304+P340-P305+P351+P338-P320-P361-P301+P330+P331-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

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