Autorizzo l’utilizzo di cookies.

Accetto Utilizziamo cookies per migliorare il nostro servizio e realizzare statistiche. Questa funzione puó essere disattivata cambiando la configurazione del browser. Continuando a navigare senza modificare questi parametri, consideriamo che l’uso di cookies sia accettato

A15684 Pyridine hydrobromide perbromide, tech. 90%

Codice CAS
39416-48-3
Sinonimi
Pyridinium bromide perbromide
Pyridinium tribromide

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
A15684-14 25g 32,70
A15684-22 100g 84,20
A15684-36 500g 269,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Pyridine hydrobromide perbromide, tech. 90%

MDL
MFCD00013223
EINECS
254-446-8

Proprietà chimiche

Formula
C5H5N•HBr3
Peso formula
319.82
Punto di fusione
128-136°
Storage & Sensitivity
Ambient temperatures.
Solubilità
Soluble in methanol, acetic acid, ethanol, n-butanol and terahydrofuran. Insoluble in water, carbon tetrachloride, ethyl bromide, benzene, toluene, ligroin, petroleum ether.

Applicazioni

Pyridine hydrobromide perbromide is used as a brominating reagent in alfa-bromination and alfa-thiocyanation of ketones, phenols, unsaturated and aromatic ethers. It is used as a raw material in the preparation of beta-adrenergic blocking agents. Furthermore, it is used as an analytical reagent.

Note

Store in cool place. Incompatible with strong oxidizing agents and strong bases.

Letteratura

Stable, crystalline, readily-handled source of bromine, useful for a wide range of brominations, including ɑ-bromination of ketones: J. Am. Chem. Soc., 70, 417 (1948), and conversion of alkenes to vic-dibromides. See, for example: Org. Synth. Coll., 5, 604 (1973), Note 2. The rate of addition to alkenes increases markedly on increased substitution, so that selective bromination of the more substituted of two double bonds can be achieved: Synthesis, 966 (1979).

In pyridine, cyclopentenones are converted directly to their ɑ-bromo derivatives (addition-elimination): Synth. Commun., 18, 1323 (1988).

Selective monobromination of anilines, predominantly at the para-position, can be effected in THF: Synth. Commun., 23, 855 (1993). In aqueous AcOH, alkyl aryl ethers are p-brominated in high yield: Synth. Commun., 28, 499 (1998), whereas aryl methyl ethers are demethylated on heating in xylene: Indian J. Chem., 33B, 288 (1994). Cleaves thioacetals in the presence of TBAB: J. Org. Chem., 46, 1745 (1981).

Hu, Y.; Ju, L.; Lu, L.; Ma, H.; Yu, X. Stereoselective alpha-indolylation of enals via an organocatalytic formal cross-coupling with indoles. Org. Biomol. Chem. 2015, 13 (33), 8869-8874.

Amaya, T.; Hirao, T. Chemistry of Sumanene. Chem Rec 2015, 15 (1), 310-321.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,7973
Beilstein
3690144
Classe di rischio
8
Gruppo di imballaggio
III
Codice tariffe armonizzato
2933.31
TSCA
Yes

Raccomandato

  • A10232

    trans-Stilbene, 98%
  • A11766

    Allyl bromide, 99%, stab. with 300-1000ppm Propylene oxide
  • A12536

    N,N,N',N'-Tetramethylethylenediamine, 99%
  • A12864

    Bromotriphenylmethane, 98%
  • A14361

    Acetanilide, 98%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio