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476-66-4 - Ellagic acid hydrate, 97%, may cont. up to 12% water - 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate - A15722 - Alfa Aesar

A15722 Ellagic acid hydrate, 97%, may cont. up to 12% water

Codice CAS
476-66-4
Sinonimi
4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate

Dimensioni Prezzo ($) Quantità Disponibilità
5g 40,17
25g 143,17
100g 447,02
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Ellagic acid hydrate, 97%, may cont. up to 12% water

MDL
MFCD00149494
EINECS
207-508-3

Proprietà chimiche

Formula
C14H6O8•xH2O
Peso formula
302.20(anhy)
Punto di fusione
450° dec.
Sensibilità
Air & Light Sensitive
Solubilità
Slightly soluble in water. Soluble in 1M sodium hydroxide (10 mg/ml), EtOH, and pyridine.

Applicazioni

Ellagic acid used as selective, ATP-competitive inhibitor of casein kinase 2. Exhibits antitumor activity and inhibits glutathione S-transferase. It is also used as a Topo I and II, FGR, GSK, and PKA inhibitor.Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma.Contact activation in blood coagulation.

Note

Air sensitive and light sensitive. Store under dry inert gas. Store in cool dry place in tightly closed container. Store in dark and away form air.

Letteratura

Patrice Njomnang Soh: Benoît Witkowski; David Olagnier; Marie-Laure Nicolau; Maria-Concepcion Garcia-Alvarez; Antoine Berry; and Françoise Benoit-Vical. In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment. Antimicrob. Agents Chemother. 2009, 31100-1106.

Sungwoo Kim; Satoru K. Nishimoto; Joel D. Bumgardnerd; Warren O. Haggardd; M. Waleed Gabere; Yunzhi Yang. A chitosan/β-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer. Biomaterials. 2010, 31 (14), 4157-4166.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3547
Beilstein
47549
Codice tariffe armonizzato
2932.20
TSCA
No
RTECS
DJ2620000

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