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107-59-5 - tert-Butyl chloroacetate, 98% - Chloroacetic acid tert-butyl ester - A15833 - Alfa Aesar

A15833 tert-Butyl chloroacetate, 98%

Codice CAS
107-59-5
Sinonimi
Chloroacetic acid tert-butyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
25g 23,90
100g 65,20
500g 244,00
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tert-Butyl chloroacetate, 98%

MDL
MFCD00000930
EINECS
203-506-1

Proprietà chimiche

Formula
C6H11ClO2
Peso formula
150.61
Punto di ebollizione
155°
Punto di infiammabilità
46°(115°F)
Densità
1.053
Indice di rifrazione
1.4230
Solubilità
Decomposes in water.

Applicazioni

tert-Butyl chloroacetate is used in the synthesis of imidazol-1-yl-acetic acid hydrochloride, cis-disubstituted aziridine ester via aza-Darzens reaction and 1,10-diaza-18-crown-6 based sensors bearing a coumarin fluorophore.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.

Letteratura

Santosh Kumar Singh.; Narendra Manne.; Purna Chandra Ray.; Manojit Pal. Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid. Beilstein Journal of Organic Chemistry. 2008, 4 42.

E Vedejs.; D W Piotrowski.; F C Tucci. Oxazolium-derived azomethine ylides. External oxazole activation and internal dipole trapping in the synthesis of an aziridinomitosene. Journal of Organic Chemistry. 2000, 65 (18), 5498-5505.

Darzens condensation (see Ethyl­ chloroacetate, A15554) with carbonyl compounds gives t-butyl glycidic esters, which readily undergo decarboxylative elimination to the homologous aldehydes. See, for example: Rec. Trav. Chim., 89, 18 (1970).

The reaction with imines has also been used in the preparation of aziridines by a nitrogen analogue of the Darzens reaction: J. Chem. Soc., Chem. Commun., 602 (1977).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H226-H302-H312-H331-H315-H319-H335

Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P273-P280h-P305+P351+P338-P309-P310a-P501a

Avoid release to the environment. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,1563
Beilstein
1753006
Classe di rischio
6.1
Gruppo di imballaggio
II
Codice tariffe armonizzato
2915.40
TSCA
Yes
RTECS
AF8985500

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