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5457-28-3 - Indole-3-carbonitrile, 98% - 3-Cyanoindole - A16041 - Alfa Aesar

A16041 Indole-3-carbonitrile, 98%

Codice CAS
5457-28-3
Sinonimi
3-Cyanoindole

Dimensioni Prezzo ($) Quantità Disponibilità
1g 34,10
5g 121,00
25g 440,00
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Indole-3-carbonitrile, 98%

MDL
MFCD00022717
EINECS
000-000-0

Proprietà chimiche

Formula
C9H6N2
Peso formula
142.16
Punto di fusione
177-182°
Sensibilità
Light Sensitive
Solubilità
Insoluble in water.

Applicazioni

Indole-3-carbonitrile is used as a synthesis reagent for preparation of 4-substituted β-lactams, biologically active indoles, inhibitors of glycogen synthase kinase 3β (GSK-3), indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors and HIV-1 integrase inhibitors. It is also used as a reactant for intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques and for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to light.

Letteratura

Didier G Pintori.; Michael F Greaney. Intramolecular oxidative C-H coupling for medium-ring synthesis. Journal of the American Chemical Society. 2011, 133 (5), 1209-1211.

F Y Miyake.; K Yakushijin, D A Horne. A concise synthesis of topsentin A and nortopsentins B and D. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2000, 2 (14), 2121-2123.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
120888
Codice tariffe armonizzato
2933.99
TSCA
No

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