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563-96-2 - Glyoxylic acid monohydrate, 97% - Oxoacetic acid monohydrate - A16058 - Alfa Aesar

A16058 Glyoxylic acid monohydrate, 97%

Codice CAS
563-96-2
Sinonimi
Oxoacetic acid monohydrate

Dimensioni Prezzo ($) Quantità Disponibilità
25g 34,70
100g 87,80
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Glyoxylic acid monohydrate, 97%

MDL
MFCD00149497
EINECS
206-058-5

Proprietà chimiche

Formula
OHCCO2H•H2O
Peso formula
92.06 (74.04anhy)
Punto di fusione
48-52°
Punto di ebollizione
100°
Punto di infiammabilità
>110°(230°F)
Sensibilità
Hygroscopic
Solubilità
Soluble in water, dimethyl sulfoxide and alcohol. Insoluble in diethyl ether and hydrocarbons.

Applicazioni

Glyoxylic acid is a reagent for sulfinylmaleate synthesis. It is one of the chemicals used in the Hopkins Cole reaction. It is involved to check the presence of tryptophan in proteins. It is condensed with urea and 1,2-diaminobenzene to form heterocycles. It also undergoes Friedel-Crafts and cyclocondensation reactions to form bis(pentamethylphenyl) acetic acid and a beta-carboline respectively. It is employed in the synthesis of a sulfinylmaleate, which serves as an efficient dienophile for enantioselective Diels-Alder cycloadditions.

Note

Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible withbases, oxidizing agents and reducing agents.

Letteratura

For reaction with tryptamine hydrochloride, followed by cyclization to give 1,2,3,4-tetrahydro-ß-carboline, see: Org. Synth. Coll., 6, 965 (1988).

Reagent for transthioacetalization of dithioacetal groups from protected aldehydes and ketones in acetic acid catalyzed by mineral acid: Synthesis, 694 (1976); for alternative methods of dithioacetal cleavage, see 1,3-Dithiane, A10505.

Lundell, J.;  Olbert-Majkut, A. Isolated glyoxylic acid-water 1: 1 complexes in low temperature argon matrices. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2015, 136, 113-121.

Ghimbeu, C. M.; Vidal, L.; Delmotte, L.; Le Meins, J. M.; Vix-Guterl, C. Catalyst-free soft-template synthesis of ordered mesoporous carbon tailored using phloroglucinol/glyoxylic acid environmentally friendly precursors. Green Chem. 2014, 16 (6), 3079-3088.

Lundell, J.;  Olbert-Majkut, A. Isolated glyoxylic acid-water 1: 1 complexes in low temperature argon matrices. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2015, 136, 113-121.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318-H317

Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.

Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,4511
Beilstein
969535
Classe di rischio
8
Gruppo di imballaggio
III
Codice tariffe armonizzato
2918.30
TSCA
Yes
RTECS
MD4550000

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