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2083-91-2 - N-(Trimethylsilyl)dimethylamine, 95% - Dimethylaminotrimethylsilane - N,N-Dimethyltrimethylsilylamine - A16550 - Alfa Aesar

A16550 N-(Trimethylsilyl)dimethylamine, 95%

Codice CAS
2083-91-2
Sinonimi
Dimethylaminotrimethylsilane
N,N-Dimethyltrimethylsilylamine

Dimensioni Prezzo ($) Quantità Disponibilità
10g 37,90
50g 112,35
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N-(Trimethylsilyl)dimethylamine, 95%

MDL
MFCD00008297
EINECS
218-222-3

Proprietà chimiche

Formula
C5H15SiN
Peso formula
117.27
Punto di ebollizione
86-87°
Punto di infiammabilità
-19°(-3°F)
Densità
0.732
Indice di rifrazione
1.3970
Sensibilità
Moisture Sensitive
Solubilità
Hydrolyzes in water.

Applicazioni

N,N-Dimethyltrimethylsilylamine was used in the synthesis of phosphoramidite. It was also employed as a reagent in the preparation of iminium salts and amides as well as for the silylation of polymers. A combination of N-(trimethylsilyl)dimethylamine and MeI was also effective to give p-methylbenzoic acid with a 85% yield based on 90% conversion from the corresponding Me ester. DETA has been treated with N-(trimethylsilyl)-dimethylamine to yield mono-, di- and tri- silylated derivatives

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, water, moisture.

Letteratura

Fourrey JL ,; Varenne J. A new and general procedure for the preparation of deoxynucleoside phosphoramidites.. Tetrahedron Lett. . 1983, 24 (19), 1963-1966.

Arihiro Iwata,; Joji Ohshita,; Heqing Tang,; Atsutaka Kunai. Ring-Opening Iodo- and Bromosilation of Lactones for the Formation of Silyl Haloalkanoates. J. Org. Chem. 2002, 67 (11), 3927-3929.

Reagent for siliylation of a wide range of functional groups, without the need for added base, useful for amino acids: J. Chromat. Sci., 7, 704 (1969). In the presence of the hindered ligand 2-(Di-tert-butyl­phosphino)­biphenyl­, L19758, Pd-catalyzed cross-coupling reactions with aryl halides to give substituted N,N-dimethylanilines have been effected: Chem. Commun., 1976 (2004).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1731861
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2931.90
TSCA
Yes

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