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106-96-7 - Propargyl bromide, 80% in toluene, stab. with MgO - 3-Bromo-1-propyne - A16580 - Alfa Aesar

A16580 Propargyl bromide, 80% in toluene, stab. with MgO

Codice CAS
106-96-7
Sinonimi
3-Bromo-1-propyne

Dimensioni Prezzo ($) Quantità Disponibilità
50ml 51,10
250ml 177,00
1000ml 626,00
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Propargyl bromide, 80% in toluene, stab. with MgO

MDL
MFCD00000241
EINECS
203-447-1

Proprietà chimiche

Formula
HC≡CCH2Br
Peso formula
118.97
Punto di fusione
-61°
Punto di ebollizione
88-90°
Punto di infiammabilità
3°(37°F)
Densità
1.335
Indice di rifrazione
1.4940
Sensibilità
Light Sensitive
Solubilità
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Applicazioni

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Note

Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.

Letteratura

Li, Y.; Cheng, B. One-pot synthesis of precise polyisoxazoles by click polymerization: Copper (I)-catalyzed 1, 3-dipolar cycloaddition of nitrile oxides with alkynes. J. Polym. Sci. A Polym. Chem. 2013, 51 (7), 1645-1650.

Un, I.; Ibisoglu, H.; Un, S. S.; Cosut, B.; Kılıc, A. Syntheses, characterizations, thermal and photophysical properties of cyclophosphazenes containing adamantane units. Inorg. Chim. Acta 2013, 399, 219-226.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H301-H335-H336-H304-H361-H373-H314

Highly flammable liquid and vapour. Toxic if swallowed. May cause respiratory irritation. May cause drowsiness or dizziness. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes severe skin burns and eye damage.

Dichiarazioni precauzionali: P210-P260-P201-P261-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
605309
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2903.39
TSCA
Yes
RTECS
UK4375000

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