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524-95-8 - 2-Aminoethyl diphenylborinate, 98% - Diphenylborinic acid 2-aminoethyl ester - (2-Aminoethoxy)diphenylborane - A16606 - Alfa Aesar

A16606 2-Aminoethyl diphenylborinate, 98%

Codice CAS
524-95-8
Sinonimi
Diphenylborinic acid 2-aminoethyl ester
(2-Aminoethoxy)diphenylborane

Dimensioni Prezzo ($) Quantità Disponibilità
5g 56,90
25g 179,00
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2-Aminoethyl diphenylborinate, 98%

MDL
MFCD00014823
EINECS
208-366-5

Proprietà chimiche

Formula
C14H16BNO
Peso formula
225.10
Punto di fusione
187-190°
Solubilità
Soluble in ethanol and methanol.

Applicazioni

2-Aminoethyl diphenylborinate is used for the densitometric determination of flavonoids and TRP activator. It is also used to manipulate intracellular release of calcium ions and in preparation of apoptotic inducers. It serves as a reactant for preparation of apoptotic inducers and in membrane-permeable SOCE (store operated calcuym entry) inhibitor.

Note

Incompatible with strong oxidizing agents.

Letteratura

Reagent for densitometric determination of flavonoids: J. Chromat., 351, 351 (1986); 437, 260 (1988).

/n

Ozaki, S.; Suzuki, A. Z.; Bauer, P. O.; Ebisui, E.; Mikoshiba, K. 2-Aminoethyl diphenylborinate (2-APB) analogues: Regulation of Ca2+ signaling. Biochem. Biophys. Res. Commun. 2013, 441 (2), 286-290.

Hofer, A.; Kovacs, G.; Zappatini, A.; Leuenberger, M.; Hediger, M. A.; Lochner, M. Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioinorg. Med. Chem. 2013, 21 (11), 3202-3213.

Yildar, M.; Aksit, H.; Korkut, O.; Ozyigit, M. O.; Sunay, B.; Seyrek, K. Protective effect of 2-aminoethyl diphenylborinate on acute ischemia-reperfusion injury in the rat kidney. J. Surg. Res. 2014, 187 (2), 683-689.

Mossaad, E.; Furuyam, W.; Enomoto,M.; Kawai, S.; Mikoshibaf, K.; Kawazu, S. Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites. Antimicrob. Agents Chemother. 2015,59 (5), 2890-2892.

Agatonovic-Kustrin, S.; Hettiarachchi, C. G.; Morton, D. W.; Razic, S. Analysis of phenolics in wine by high performance thin-layer chromatography with gradient elution and high resolution plate imaging. J. Pharm. Biomed. Anal. 2015, 102, 93-99.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2942273
Codice tariffe armonizzato
2931.90
TSCA
No
RTECS
ED6150000

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