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It is applied in organic synthesis, lacquers, polyester adhesives, and urethane elastomers. Azelaic acid directly inhibits kallikrein 5 (KLK5), down regulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and up regulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPAR? is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis. It is a component of a number of hair and skin conditioners. Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne. It is used in lubrication and plasticizers.
M.R. Gasco, et al. In vitro permeation of azelaic acid from viscosized microemulsions.Int. J. Pharm.,1991,69(3), 193-196.
Graupe K, et al. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.European Pubmed.,1996,57/span>(1), 20-35.