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431-47-0 - Methyl trifluoroacetate, 98+% - Trifluoroacetic acid methyl ester - A17338 - Alfa Aesar

A17338 Methyl trifluoroacetate, 98+%

Codice CAS
431-47-0
Sinonimi
Trifluoroacetic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
50g 53,90
250g 238,00
1000g 829,00
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Methyl trifluoroacetate, 98+%

MDL
MFCD00000417
EINECS
207-074-5

Proprietà chimiche

Formula
CF3CO2CH3
Peso formula
128.05
Punto di fusione
-78°
Punto di ebollizione
43-44°
Punto di infiammabilità
-18°(-0.4°F)
Densità
1.283
Indice di rifrazione
1.2900
Sensibilità
Moisture Sensitive
Solubilità
Not miscible or difficult to mix in water.

Applicazioni

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

Note

Moisture sensitive. Store away from strong bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Letteratura

Langlois BR and Roques N. Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate.J. Fluor. Chem.,2007,128(10), 1318-1325.

M. N. Vargaftik, et al. Highly selective partial oxidation of methane to methyl trifluoroacetate.J. Chem. Soc., Chem. Commun.,1990,15, 1049-1050.

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, A12314, has also been used for the N-acylation of amino acids: Synthesis, 399 (1976).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1756070
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2915.90
TSCA
Yes

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