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It is employed as pharmaceutical and agrochemical intermediate. It is used as an alkylation agent for mercaptans and other sulfur containing compounds.
H Xiao.; J Liu.; Z Li. Catalysis of the hydrolysis of ethyl mandelate and esterification of alpha-bromopropionic acid by lipase in microemulsions.Chin J Biotechnol.1993,9(1), 33-39.
Hari M R Gardimalla.; Deendayal Mandal.; Philip D Stevens.; Max Yen.; Yong Gao. Superparamagnetic nanoparticle-supported enzymatic resolution of racemic carboxylates.Chem Commun (Camb).2005,354432-4434.
Reaction of ɑ-halo alkanoic acids with a dialkyl phosphite in the presence of NaH, followed by treatment of the resulting phosphonoacetate salt with an aldehyde (or cycloalkanone) provides a convenient one-pot alternative to the Knoevenagel or Horner-Wadsworth-Emmons reactions for the synthesis of a variety of substituted acrylic acids: J. Org. Chem., 46, 2514 (1981):
For a simplified variant of the reaction, applicable to the synthesis of ɑ-unsubstituted cinnamic acids, see Chloroacetic acid, A11482.
Dichiarazioni di rischio (UE): H301-H314-H318
Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P260u-P201-P280i-P304+P340-P405-P501a
Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.