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3,5-Bis(bromomethyl)toluene is used as an anastrazole intermediate for the preparation of medicines and other fine chemicals. It is used as letrozole intermediates which is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
John Hurtado; Andrés Ibañez; René Rojas; Mauricio Valderrama. Palladium(II) complexes bearing the new pincer ligand 3,5-bis(indazol-2-ylmethyl)toluene; synthesis and catalytic properties. Inorganic Chemistry Communications. 2010, 13 (9), 1025-1028.
Virgil Boekelheide; Rodger W. Griffin Jr. Synthesis of [2.2]metacyclophanes. J. Org. Chem. 1969, 34 (6), 1960-1961.
Dichiarazioni di rischio (UE): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.