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75-80-9 - 2,2,2-Tribromoethanol, 99% - 2,2,2-Tribromoethyl alcohol - A18706 - Alfa Aesar

A18706 2,2,2-Tribromoethanol, 99%

Codice CAS
75-80-9
Sinonimi
2,2,2-Tribromoethyl alcohol

Dimensioni Prezzo ($) Quantità Disponibilità
5g 26,50
25g 77,20
100g 233,00
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2,2,2-Tribromoethanol, 99%

MDL
MFCD00004671
EINECS
200-903-1

Proprietà chimiche

Formula
Br3CCH2OH
Peso formula
282.76
Punto di fusione
77-80°
Punto di ebollizione
92-93°/10mm
Sensibilità
Light Sensitive
Solubilità
Soluble in alcohol, ether, benzene and warmpetroleum ether. Partially soluble in water.

Applicazioni

2,2,2-Tribromoethanol is utilized in organic synthesis of beta-amino alcohols. The pharmaceutical preparation of tribromoethanol serves as an anesthetic in medicine.

Note

Light Sensitive. Store in cool and well ventilated area. Keep container tightly closed.

Letteratura

Carboxyl groups can be protected as tribromoethyl esters, e.g. by reaction of the acid chloride in the presence of N,N-dimethylaniline. The group is readily cleaved with Zn/AcOH: J. Chem. Soc., Pekin 1., 2875 (1993); (cf. 2,2,2-Trichloroethanol, L08163). The group has also been exploited in the activation of carboxylic acids for amidation with amines, by reductive cleavage of the tribromoethyl ester with a P(III) reagent, preferably Hexamethyl­phosphorous triamide, A12571, and triethylamine. In an analogous esterification method with alcohols, tributylphosphine - DMAP was the preferred system: J. Org. Chem., 64, 1430 (1999).

Maheras, K. J.; Gow, A. Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics. 2013, 219 (1), 61-69.

Jong, W. M. C.; Zuurbier, C. J.; Winter, R. J.; Van den Heuvel, D. A. F.; Reitsma, P. H.; Cate, H. T.; Ince, C. Fentanyl-fluanisone-midazolam Combination Results in More Stable Hemodynamics than does Urethane-α-chloralose and 2,2,2-tribromoethanol in Mice. 2002, 41 (3), 28-32.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1733249
Codice tariffe armonizzato
2905.59
TSCA
Yes
RTECS
KM3675000

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