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52509-14-5 - (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98% - A18882 - Alfa Aesar

A18882 (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98%

Codice CAS
52509-14-5
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
10g 59,10
50g 206,00
250g 873,00
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(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98%

MDL
MFCD00011966
EINECS
257-977-3

Proprietà chimiche

Formula
C22H22BrO2P
Peso formula
429.30
Punto di fusione
186-189°
Sensibilità
Hygroscopic
Solubilità
Soluble in water (20°C).

Applicazioni

It finds its applications as a reagent for Wittig olefinations with introduction of a 1,3-dioxolane moiety. It is applied as a reactant for the preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione, for microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II, for the preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands, in the synthesis and antitumor agents, in regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization.

Note

Hygroscopic. Store away from water/moisture and oxidizing agents. Store under inert gas. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Lin Yuan.; Weiying Lin.; Yueting Yang. A ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione based on the drastic distinction in the kinetic profiles.Chem. Commun. (Camb).2011,47(22), 6275-6277.

Eva Große Maestrup.; Christian Wiese.; Dirk Schepmann.; Peter Brust.; Bernhard Wünsch. Synthesis, pharmacological activity and structure affinity relationships of spirocyclic ?1 receptor ligands with a (2-fluoroethyl) residue in 3-position.Bioorg Med Chem.2011,19(1), 393-405.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2932.99
TSCA
No

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