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1118-68-9 - N,N-Dimethylglycine, 98+% - Dimethylaminoacetic acid - A19670 - Alfa Aesar

A19670 N,N-Dimethylglycine, 98+%

Codice CAS
1118-68-9
Sinonimi
Dimethylaminoacetic acid

Dimensioni Prezzo ($) Quantità Disponibilità
5g 53,90
25g 201,00
100g 649,00
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N,N-Dimethylglycine, 98+%

MDL
MFCD00004283
EINECS
214-267-8

Proprietà chimiche

Formula
C4H9NO2
Peso formula
103.12
Punto di fusione
179-183°
Sensibilità
Hygroscopic
Solubilità
Soluble in water.

Applicazioni

N,N-Dimethylglycine is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role for the development of glycine-based ionic liquids and emulsifiers.

Note

Hygroscopic. Incompatible with strong oxidizing agents.

Letteratura

Additive which promotes the Heck coupling reaction of unactivated aryl chlorides with alkenes, catalyzed by Pd(II) in the presence of Tetraphenyl­phosphonium chloride, A10575: Angew. Chem. Int. Ed., 37, 481 (1998). The combination with Bis(benzonitrile)dichloropalladum constitutes a highly active phosphine-free catalyst system for Heck reactions of aryl bromides: Tetrahedron Lett., 39, 8449 (1998); see also: Tetrahedron Lett., 39, 8449 (1998). Promotes the copper(I)-catalyzed Ullmann-type coupling of aryl bromides and iodides with amines: Org. Lett., 5, 2453 (2003), and phenols: Org. Lett., 5, 3799 (2003), to give substituted anilines and diaryl ethers, respectively. Aryl iodides can also be coupled with aliphatic alcohols to give aryl alkyl ethers: Synlett, 243 (2007). In combinatiion with CuI, vinyl halides with phenols give aryl vinyl ethers: Synlett, 1767 (2005).

McEntyre, C. J.; Lever, M.; Chambers, S. T.; George, P. M.; Slow, S.; Elmslie, J. L.; Florkowski, C. M.; Lunt, H.; Krebs, J. D. Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Ann. Clin. Biochem. 2015, 52 (3), 352-360.

Kapustin, E. A.; Minkov, V. S.; Stare, J.; Boldyreva, E. V. One Hydrogen Bond-Two Ways To Build a Structure. The Role of N-H···O Hydrogen Bonds in Crystal Structures of N,N-Dimethylglycine. Cryst. Growth Des. 2014, 14 (4), 1851-1864.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302

Harmful if swallowed.

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,3244
Codice tariffe armonizzato
2922.49
TSCA
Yes
RTECS
MB9865000

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