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75-05-8 - Acetonitrile, 99% - Methyl cyanide - Cyanomethane - A19862 - Alfa Aesar

A19862 Acetonitrile, 99%

Codice CAS
75-05-8
Sinonimi
Methyl cyanide
Cyanomethane

Dimensioni Prezzo ($) Quantità Disponibilità
500ml 30,10
2500ml 89,20
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Acetonitrile, 99%

MDL
MFCD00001878
EINECS
200-835-2

Proprietà chimiche

Formula
C2H3N
Peso formula
41.05
Punto di fusione
-48°
Punto di ebollizione
80-82°
Punto di infiammabilità
5°(41°F)
Densità
0.786
Indice di rifrazione
1.3440
Solubilità
Miscible with water, alcohols, ethers, acetone, chloroform, carbon tetrachloride and ethylene chloride. Immiscible with saturated hydrocarbons (petroleum fractions).

Applicazioni

Acetonitrile is utilized as a polar aprotic solvent in organic synthesis, and in the purification of butadiene. It is used in all the analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry (LC-MS). It is used for the extraction of fatty acids, spinning fibers and casting and molding of plastic materials. Aqueous two-phase systems based on acetonitrile and carbohydrates play an important character in the extraction and purification of biomolecules called vanillins. It acts as a stabilizer for the chlorinated solvents, and finds use in the production of DNA oligonucleotides.

Note

Incompatible with alkali metals, acids, bases, reducing agents and oxidizing agents. Highly flammable. Store it away from heat, sparks, and flame exposure.

Letteratura

Polar aprotic solvent for a wide variety of reactions, including nucleophilic substitutions, oxidations, reductions and organometallic reactions. Widely used with crown ethers for the generation of 'naked' anions from their salts; see, e.g. 18-Crown-6, A11249 . Preferred solvent for RuO4 oxidations, due to its coordinating ability; see Ruthenium(III)­ chloride hydrate, 11043 .

Undergoes the Ritter reaction with alcohols or olefins in the presence of acid to give N-substituted acetamides. For benzylic alcohols, modified conditions employing boron trifluoride etherate give high yields: Synth. Commun., 24, 601 (1994). For an example, see 4-Methyl­benzyl­ alcohol, A15315 .

For use in the mild conversion of amides to nitriles, see Benzamide, A10501 .

Cardoso, G. B.; Mourao, T.; Pereira, F. M.; Freire, M. G.; Fricks, A. T.; Soares, C. M. F.; Lima, A. S. Aqueous two-phase systems based on acetonitrile and carbohydrates and their application to the extraction of vanillin. J. Electroanal. Chem. 2007, 608 (2), 141-147.

Lam, T. W.; Zhang, H.; Siu, S. K. Reductions of Oxygen, Carbon Dioxide, and Acetonitrile by the Magnesium(II)/Magnesium(I) Couple in Aqueous Media: Theoretical Insights from a Nano-Sized Water Droplet. J. Phys. Chem. A 2015, 119 (12), 2780-2792.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H302-H312-H332-H319

Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes serious eye irritation.

Dichiarazioni precauzionali: P210-P261-P280-P303+P361+P353-P305+P351+P338-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,70
Beilstein
741857
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2926.90
TSCA
Yes
RTECS
AL7700000

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