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1875-48-5 - N-Aminophthalimide, 94% - A19914 - Alfa Aesar

A19914 N-Aminophthalimide, 94%

Codice CAS
1875-48-5
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
5g 41,20
10g 66,95
50g 222,57
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N-Aminophthalimide, 94%

MDL
MFCD00005895
EINECS
217-505-9

Proprietà chimiche

Formula
C8H6N2O2
Peso formula
162.15
Punto di fusione
ca 195° dec.
Solubilità
Solubility in hot methanol almost transparent.

Applicazioni

It is employed in the aziridination of chiral N-enoyl sultams. It is also used in the synthesis of n-phthalimidoaziridines

Note

Store away from oxidizing agents, strong bases and heat. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.

Letteratura

Kung-Shou Yang.; Kwunmin Chen. Enantioselective aziridination of alkenes with N-aminophthalimide in the presence of lead tetraacetate-mediated chiral ligand.Org Lett.2002,4(7), 1107-1109.

David J. Anderson, et al. Reactive intermediates. Part XXII. Formation of 2H-azirines by oxidation of N-aminophthalimide in the presence of alkynes.J. Chem. Soc., Perkin Trans. 1.1973,550-555.

May be oxidized with lead(IV) acetate to "phthalimidonitrene", which adds to alkenes to give aziridines. The phthalimido group can be cleaved with hydrazine hydrate: J. Chem. Soc. (C), 576 (1970); J. Am. Chem. Soc., 92, 1784 (1970); Helv. Chim. Acta, 55, 1276 (1972); Org. Synth. Coll., 6, 56 (1988). Addition to cyclopentadienes leads to substituted pyridines after ring-opening with base: Heterocycles, 22, 1369 (1984). Addition to the (racemic) acrylic ester below shows an extremely high facial selectivity, adding to the less hindered side (290:1): Helv. Chim. Acta, 72, 1095 (1989).

Aziridination has also been achieved in high yield by electrochemical oxidation: J. Am. Chem. Soc., 124, 530 (2002).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
383756
Codice tariffe armonizzato
2933.99
TSCA
No

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