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B20010 Probenecid, 98%

Codice CAS
57-66-9
Sinonimi
4-(Di-n-propylaminosulfonyl)benzoic acid
4-(Di-n-propylsulfamoyl)benzoic acid

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
B20010-88 2.5g 49,80
B20010-09 10g 151,00
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Probenecid, 98%

MDL
MFCD00038402
EINECS
200-344-3

Proprietà chimiche

Formula
C13H19NO4S
Peso formula
285.36
Punto di fusione
198-199°
Storage & Sensitivity
Ambient temperatures.
Solubilità
Soluble in water (partly miscible), solutions of alkali hydroxides,, ethanol (100 mM), acetone, chloroform, sodium hydroxide (1 M), DMSO (100 mM), methanol, dilute acids (practically insoluble), dilute alkalies, and ether (slightly soluble).

Applicazioni

It is a uricosuric drug, that is, it increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Campos-Arroyo D, et al. Probenecid is a chemosensitizer in cancer cell lines.Cancer chemotherapy and pharmacology.1992,69(2), 495-504.

Robbins N, et al. The history and future of probenecid.Cardiovascular toxicology.2012,12(1), 1-9.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,7754
Codice tariffe armonizzato
2935.90
TSCA
Yes
RTECS
DG9400000

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