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667-27-6 - Ethyl bromodifluoroacetate, 97% - Bromodifluoroacetic acid ethyl ester - B20461 - Alfa Aesar

B20461 Ethyl bromodifluoroacetate, 97%

Codice CAS
667-27-6
Sinonimi
Bromodifluoroacetic acid ethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 18,55
5g 62,01
25g 190,40
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Ethyl bromodifluoroacetate, 97%

MDL
MFCD00042069
EINECS
211-567-0

Proprietà chimiche

Formula
BrCF2CO2CH2CH3
Peso formula
202.99
Punto di ebollizione
112-114°
Punto di infiammabilità
21°(69°F)
Densità
1.583
Indice di rifrazione
1.3880
Solubilità
Soluble in most organic solvents.

Applicazioni

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

Letteratura

S Marcotte.; X Pannecoucke.; C Feasson. Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines. J. Org. Chem. 199964 ( 23), 8461-8464.

A Sorochinsky.; N Voloshi.; A Markovsky. Convenient Asymmetric Synthesis of β-Substituted α,α-Difluoro-β-amino Acids via Reformatsky Reaction between Davis' N-Sulfinylimines and Ethyl Bromodifluoroacetate. J. Org. Chem. 200368 ( 19), 7448-7454.

Valuable building block for the introduction of the CF2 group by Reformatsky reaction with aldehydes. A further development of this chemistry involves the generation of an ɑɑ-difluoro-ß-lactone, followed by thermal decarboxylation as a high-yield route to 1,1-difluoroalkenes: J. Org. Chem., 60, 5378 (1995):

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1906095
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2915.90
TSCA
No

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