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83-49-8 - Hyodeoxycholic acid, 96% - 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid - B20506 - Alfa Aesar

B20506 Hyodeoxycholic acid, 96%

Codice CAS
83-49-8
Sinonimi
3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid

Dimensioni Prezzo ($) Quantità Disponibilità
5g 44,46
25g 153,47
100g 526,33
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Hyodeoxycholic acid, 96%

MDL
MFCD00003681
EINECS
201-483-2

Proprietà chimiche

Formula
C24H40O4
Peso formula
392.59
Punto di fusione
197-199°
Solubilità
Solubility in methanol, very faint turbidity. Slightly soluble in alcohol, acetone, ether and very slightly soluble in chloroform.

Applicazioni

It is the main acid constituent of hog bile, and for this reason it was used industrially as precursor for steroid synthesis before total synthesis became practical.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.J. Med. Chem.2008,51(6), 1831-1841.

Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice.FASEB J.2013,27(9), 3805-3817.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,4857
Codice tariffe armonizzato
2918.19
TSCA
No
RTECS
FZ2050000

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