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1126-09-6 - Ethyl isonipecotate, 98% - Ethyl piperidine-4-carboxylate - H-DL-Inp-OEt - B20601 - Alfa Aesar

B20601 Ethyl isonipecotate, 98%

Codice CAS
1126-09-6
Sinonimi
Ethyl piperidine-4-carboxylate
H-DL-Inp-OEt

Dimensioni Prezzo ($) Quantità Disponibilità
25g 31,96
100g 103,00
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Ethyl isonipecotate, 98%

MDL
MFCD00006003
EINECS
214-416-7

Proprietà chimiche

Formula
C8H15NO2
Peso formula
157.21
Punto di ebollizione
203-205°
Punto di infiammabilità
80°(176°F)
Densità
1.021
Indice di rifrazione
1.4600
Solubilità
Fully miscible with water.

Applicazioni

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Note

Store at room temperature. Incompatible with strong oxidizing agents.

Letteratura

Samantha J. Barry.; Richard M. Carr.; Stephen J. Lane.; William J. Leavens.; Soraya Monté.; Ian Waterhouse. Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives.rapid communications in mass spectroscopy. 2003 , 17 (6),603-620 .

Stephen A. Kolodziej.; Susan L. Hockerman.; Gary A. DeCrescenzo.; Joseph J. McDonald.; Debbie A. Mischke.; Grace E. Munie.; Theresa R. Fletcher.; Nathan Stehle.; Craig Swearingen.; Daniel P. Becker. MMP-13 selective isonipecotamide α-sulfone hydroxamates.Bioorg. Med. Chem. Lett. 2010, 20 (12),3561-3564 .

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
118419
Codice tariffe armonizzato
2933.39
TSCA
No

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