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194853-86-6 - 4-Fluoro-2-(trifluoromethyl)benzonitrile, 98+% - 2-Cyano-5-fluorobenzotrifluoride - alpha,alpha,alpha,4-Tetrafluoro-o-tolunitrile - B20617 - Alfa Aesar

B20617 4-Fluoro-2-(trifluoromethyl)benzonitrile, 98+%

Codice CAS
194853-86-6
Sinonimi
2-Cyano-5-fluorobenzotrifluoride
alpha,alpha,alpha,4-Tetrafluoro-o-tolunitrile

Dimensioni Prezzo ($) Quantità Disponibilità
1g 45,92
5g 169,60
25g 910,52
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4-Fluoro-2-(trifluoromethyl)benzonitrile, 98+%

MDL
MFCD00061283
EINECS
000-000-0

Proprietà chimiche

Formula
C8H3F4N
Peso formula
189.11
Punto di fusione
43-45°
Punto di ebollizione
194-196°
Densità
1.350
Solubilità
Insoluble in water. Solubility in methanol is almost transparent.

Applicazioni

It is used as a pharmaceutical intermediate. It is also used for the synthesis of diphenylthioethers.

Note

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Jie Jack Li, et al. Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications.J. Med. Chem.,2008,51(21), 7010-7014.

Lorna Mitchell, et al. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.Bioorganic & Medicinal Chemistry Letters.2009,19(5), 1310-1313.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H331-H302-H312-H315-H319-H335

Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P311-P362-P301+P312-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2926.90
TSCA
No

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