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17201-43-3 - 4-(Bromomethyl)benzonitrile, 98% - alpha-Bromo-p-tolunitrile - 4-Cyanobenzyl bromide - B20641 - Alfa Aesar

B20641 4-(Bromomethyl)benzonitrile, 98%

Codice CAS
17201-43-3
Sinonimi
alpha-Bromo-p-tolunitrile
4-Cyanobenzyl bromide

Dimensioni Prezzo ($) Quantità Disponibilità
5g 45,70
25g 169,00
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4-(Bromomethyl)benzonitrile, 98%

MDL
MFCD00001829
EINECS
241-246-0

Proprietà chimiche

Formula
C8H6BrN
Peso formula
196.05
Punto di fusione
113-117°
Solubilità
Soluble in chloroform and methanol. Insoluble in water.

Applicazioni

4-(Bromomethyl)benzonitrile is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.

Note

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents, strong acids and bases.

Letteratura

Alcohols can be protected as their 4-cyanobenzyl ethers, e.g. in the presence of NaH. They can be selectively cleaved by electrolytic reduction: Tetrahrdon Lett., 2643 (1979); Chem. Ber., 114, 946 (1981).

Snelling, R.; Saavedra, J. Z.; Bayrasy, P.; Abdollahian, Y.; Singaram, B. Binary reducing agents containing dichloroindium hydride for the selective, partial, or tandem reductions of bifunctional compounds consisting of halo-nitriles, halo-esters and halo-carboxylic acids. Org. Chem. Front. 2015, 2 (2), 133-140.

Bagala, D. B.; Bhanagea, B. M. Recent Advances in Transition Metal-Catalyzed Hydrogenation of Nitriles. Adv. Synth. Catal. 2015, 357 (5), 883-900.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H301-H311-H331-H317-H314-H318

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. May cause an allergic skin reaction. Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P261-P280-P301+P310-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
636717
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2926.90
TSCA
Yes

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