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It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.
Enrico T Nadres, et al. Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.J Org Chem.,201176(2), 471-483.
Teruhisa Tsuchimoto, et al. Reductive alkylation of indoles with alkynes and hydrosilanes under indium catalysis.Org Lett.201113(5), 912-5.
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a
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