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It is an antifibrinolytic agent that is found to inhibit plasmin-induced fibrinolysis. Used in various hemorrhagic diseases , abnormal bleeding in operations. It is also used as a lysine analogue to characterize binding sites in plasminogen.
J M Marshall, et al. Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen.Biochem.,199433/span>(12), 3599-3606.
G J Hoover et. al. Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with µ-amino acids.Biochemistry.,199332(41), 10936-10943.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.